(E,E)-Bis(2-hydroxybenzylidene)acetone (2-HBA)
(E,E)-Bis(2-hydroxybenzylidene)acetone (2-HBA)
CAS: 131359-24-5
Molecular Formula: C17H14O3
(E,E)-Bis(2-hydroxybenzylidene)acetone (2-HBA) - Names and Identifiers
(E,E)-Bis(2-hydroxybenzylidene)acetone (2-HBA) - Physico-chemical Properties
| Molecular Formula | C17H14O3 |
| Molar Mass | 266.29 |
| Solubility | DMSO: soluble15mg/mL (clear solution) |
| Appearance | powder |
| Color | white to beige |
| Storage Condition | Sealed in dry,Store in freezer, under -20°C |
| In vitro study | When L1210 cells are exposed to 0.6 μM 2-HBA (bis(2-hydroxy-benzylidene)acetone), the specific activities of NQO1 and glutathione reductase increase by 6- and 1.5-fold, respectively. The total cellular glutathione content is also coordinately induced by 2.4-fold. In a more detailed study it is found that NQO1 is induced by 2-HBA in a concentration-dependent manner. Treatments with 2-HBA cause cell cycle arrest and apoptosis in both L1210 wild type cells and their Y8 drug-resistant counterparts in a concentration-dependent manner. 2-HBA can also activate caspase-3 and caspase-10. |
(E,E)-Bis(2-hydroxybenzylidene)acetone (2-HBA) - Risk and Safety
| WGK Germany | 3 |
(E,E)-Bis(2-hydroxybenzylidene)acetone (2-HBA) - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.755 ml | 18.777 ml | 37.553 ml |
| 5 mM | 0.751 ml | 3.755 ml | 7.511 ml |
| 10 mM | 0.376 ml | 1.878 ml | 3.755 ml |
| 5 mM | 0.075 ml | 0.376 ml | 0.751 ml |
Last Update：2024-01-02 23:10:35
(E,E)-Bis(2-hydroxybenzylidene)acetone (2-HBA) - Reference Information
| biological activity | 2-HBA is an effective NAD(P)H: quinone receptor oxidoreductase 1 (NQO1) inducer, can also activate caspase-3 (caspase-3) and caspase-10 (caspase-10). |
| target | Caspase-3 Caspase-10 |
| in vitro study | When L1210 cells are exposed to 0.6 μM 2-HBA (bis(2-hydroxy-benzylidene)acetone), the specific activities of NQO1 and glutathione reductase increase by 6- and 1.5-fold, respectively. The total cellular glutathione content is also coordinately induced by 2.4-fold. In a more detailed study it is found that NQO1 is induced by 2-HBA in a concentration-dependent manner. Treatments with 2-HBA cause cell cycle arrest and apoptosis in both L1210 wild type cells and their Y8 drug-resistant counterparts in a concentration-dependent manner. 2-HBA can also activate caspase-3 and caspase-10. |
Last Update：2024-04-09 01:59:59
Supplier List
Spot supply
Product Name: 2-HBA Visit Supplier Webpage Request for quotationCAS: 131359-24-5
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: (E,E)-Bis(2-hydroxybenzylidene)acetone (2-HBA) Visit Supplier Webpage Request for quotationCAS: 131359-24-5
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: 2-HBA Visit Supplier Webpage Request for quotationCAS: 131359-24-5
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: (E,E)-Bis(2-hydroxybenzylidene)acetone (2-HBA) Visit Supplier Webpage Request for quotationCAS: 131359-24-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Spot supply
Product Name: 2-HBA Visit Supplier Webpage Request for quotationCAS: 131359-24-5
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: (E,E)-Bis(2-hydroxybenzylidene)acetone (2-HBA) Visit Supplier Webpage Request for quotationCAS: 131359-24-5
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: 2-HBA Visit Supplier Webpage Request for quotationCAS: 131359-24-5
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: (E,E)-Bis(2-hydroxybenzylidene)acetone (2-HBA) Visit Supplier Webpage Request for quotationCAS: 131359-24-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
(E,E)-Bis(2-hydroxybenzylidene)acetone (2-HBA)
(Z)-3-hexenyl glucoside
NSC 306222
1,3,2-DIOXABOROLANE, 2-[3,4-BIS(HEXYLOXY)PHENYL]-4,4,5,5-TETRAMETHYL-
2-Oxa-7-azaspiro[3.5]nonane-7-carboxylic acid, 1,1-dimethylethyl ester
灵芝(南韩芝)
1-Isoxazol-5-yl-ethylamine dihydrochloride
[R,(+)]-4-Hydroxyhexanoic acid lactone
152369-60-3
5-溴酮基THF杂质
(Z)-3-hexenyl glucoside
NSC 306222
1,3,2-DIOXABOROLANE, 2-[3,4-BIS(HEXYLOXY)PHENYL]-4,4,5,5-TETRAMETHYL-
2-Oxa-7-azaspiro[3.5]nonane-7-carboxylic acid, 1,1-dimethylethyl ester
灵芝(南韩芝)
1-Isoxazol-5-yl-ethylamine dihydrochloride
[R,(+)]-4-Hydroxyhexanoic acid lactone
152369-60-3
5-溴酮基THF杂质